I have tried looking everywhere for a solution to my problem. I'm running a standard 1/4 cable from my guitar to the Pro X. I am then running two 1/4 uncompressed signals into a Scarlett 2i2, which I WILL continue using. From the Scarlett outputs, I have 2 JBL 305's. I can hear the guitar only when the direct monitoring feature is used. No other sounds play from these speakers. I have chosen the 2i2 as my playback device in Windows as well as the ASIO driver in Cubase. Both of these units are connected direcly to the computer via USB. Cubase does not recognize the guitar sound, for the mix console shows nothing playing. All drivers are up to date and I am running out of ideas. I tried a Yamaha MX49 keyboard and it ended up recording in Cubase but there is still no playback sound. I've even gone as far as completely taking the 2i2 out of the equation (Speakers plugged into the POD) and Cubase did recognize the sound but I continued to not get playback sound. I appreciate any help I can get. Thank you.