Depends upon what you mean by "compatible." You may use it as you would any effect pedal in-line between your guitar and the amp, but it will be a mono signal into the Amplifi. Anything you do from the Amplifi app will then affect your input signal as designed. Not sure what the benefit would be to run it that way, but trial & error will provide that answer for you. If you're looking for sound changes via pedal, I would consider purchase of a compatible pedal and just set up your chosen tones into the banks from within the app. Prior to doing so, I would backup each "stock" tone to "my tones" so you can overwrite any of those factory tones with your custom mods in any order you want; the backups give you access to those factory tones for recall any time you may want without having to flash the firmware in order to restore factory presets. Unfortunately, you have to do it one at a time by first choosing each tone, then saving to "my tones" one by one. It's time consuming, but hopefully you'll get away with doing only one time.