I have had this same problem. At first my reverb would randomly change mix levels and if I turned it off it would turn back on by itself. I tried contact cleaner which seemed to solve the problem for awhile, but now it seems to have spread to the main volume knob too. I suspect it may be the PCB.
I emailed Line6 and they said the unit would need repair, but since I’m out of warranty I’d be footing the bill. Not too happy about that because I don’t use the unit all that much...