Hi kryhan,
I can't manually install the drivers via Device Manager as the Line 6 POD 300 cannot be detected. There's no unknown device or whatsoever that exists in the DM.
I have actually bought an HD 500 recently, and it was detected on the same PC that i am using. No problem/issues at all. I don't know anymore, it could be a hardware issue that needs to be serviced. :(