For what its worth, I use the 4CM with the Helix and an Orange TH30. I like the clean and dirty channels on the TH30, so I mainly use the Helix for routing and effects but lately I've been getting a little creative with the Helix preamps straight into the power amp section of the TH30. I just bypass the Orange head through the routing and it works fantastic. I get the tone of the TH30 when I want it and still have the ability to play with some different preamp tones for certain parts of songs.