My problems started from Deskew Gig Performer 3, it threw the "crash to desk" upon me when adding or switching to Softube Amp Room (VST3). I had a different rig in there with an ENGL E765RT, an SSL channel strip and a Lexicon MPX reverb running fine. The other rig was just the Helix Native, and it had no problems for at least a few days.
I have a crazy amount of plugins (good, paid for, and well known) that have run very nicely for most of 2 years now (on this build).
A home-built ASUS Pro WS X570-ACE workstation mb/Ryzen 7 3800X PC tower that has more power than I can currently use - for DAW/plugins, running solid as a rock. 64GB of 3200 Ballistix.
I have 4 (2TB drives), 2 of those are old school spin drives that can be defragged. They are for installation programs/backup/miscellaneous use only. No shortage of space on any, - fast Samsung 970 NVMe main drive, and an 860 EVO SATA.
I am NOT a slouch in updates & maintenance, quite the opposite actually.
Speaking of scrambled, Windows 11 just did exactly that today with a few updates at once. I was left with NO start menu, NO search ability, and NO Windows App store (don't really use it but...). Just weird, because it had me believing it was smooth as W10 was before that bs.
Luckily I have a full Windows 10 Pro drive/system image backup (if I need), and the old W7 System Restore points stills works well. I am probably going to be using the image back to W10 Pro, but I'll at least give this a bit longer to see if it was just a bum update.
Anyhow, the issues were from W10 Pro, and still present in W11 Pro. I have tried to uninstall/reinstall/different combos of VST2/VST3 (one, other, or both) and their folder locations. Nothing yet. I'd certainly try the last version of Helix if I had it, but nowhere to get it, Line 6 doesn't leave it up, after the new one comes out.
And yeah, my Helix Native worked just fine on my MSI DAW laptop too, before this. I can't just go for a reinstall for 1 plugin (Helix). Softube Amp Room works in everything else but GP3, perfectly.
I uninstalled Deskew GP3, so right now it is only Helix that is goofing up - out of probably close to 1000 plugins according to Studio One 4.5