THANK YOU so much. After a few days of playing around, here's what I've found based on your recommendations:
Compressor: I like the feel of the compressor engaged, as opposed to taking it out completely, so I left it in with a +2db level boost (this is an "always on" pedal)
Raised mids: definitely helped - raised on my amp to about an 8, presence at 5-6, and EQ with a +2db level increase (using the "Simple EQ" block)
Drive: I already play with a fairly clean tone, but I increased it on the amp models a bit and also tweaked the one drive pedal I have in the signal chain to be more "balanced" when engaged
High/low cuts: playing with a strat, the highs can be almost too piercing at times, so I actually increased the high cut on the amp/cab a pretty good amount and that has helped a lot
EQ: Already at the end of my chain, your higher mids/high frequencies tip helped
Cab mic: this might have been the biggest positive change. I was using the stock mic model that came with each cab, but the 57 Dynamic at 2 inches helped incredibly. No more thin sounding tones with the ribbon mics some of my patches were using.
Cab level: added a +2db increase and that also helped with a more full sound
Delays/reverb: these are absolutely necessary for a church worship band setting, but the above changes helped me dial in less of a delay/reverb to not lose anything in the overall mix
Global EQ: didn't touch this, want to try to avoid tweaking this since it's more of a "venue by venue" basis change that it should be used for.
Again, many thanks for these tips! Hope this helps anyone else out there too!