Add me to the list of people saved by this!
After a Win10 clean install, neither Helix Native nor Helix Edit would run. Someone on TGP pointed me here and, sure enough, I found that the drive allocated as Disk 0 (non-system) was showing offline. A quick re-seat of a sata cable and I was back in business.
On my TGP post, Frank Ritchotte responded promptly and recognized the issue and said it would be addressed in v3.0. (my TGP post is also under "Spemph")
Thanks to Camelot_One for the work here and to SwirlyMaple at TGP for pointing me here!!