When I loaded the ASIO driver and selected the Catalyst in Reaper I could see input 1-4 and outs 1&2 as expected. Recorded all 4 inputs simultaneously. 1&2 had the amp models with effects and 3&4 were DI guitar bypassing all the processing.
Did not try any re-amping but I suppose it would be dry, clean guitar to the available amp model, cab, mic combinations. No way to use daw IRs separately.