I think Helix LT would be ideal for you. You can even use your stomp boxes in the FX loop if you have some you want to keep.
Helix sounds great and is easy to use, has the same processing as the bigger Helix, just fewer connection options (which are still abundant enough for many routing setups).
The effects pedals are effectively indistinguishable from the real thing, and so are the amps. I have A/B'd some of the amps against Helix and many times could not tell which was which as I switched back and forth.
I have three Helix LT now (two at home and one at my vacation home).
I can freely move my patches from one to another (using HX Edit and a USB stick that came with Helix) so they are all effectively identical.
I still use my tube amps occasionally at my home studio with a UA OX Box, but Helix goes with me wherever I travel and is my primary rig.
You will need at least one solid P/A (FRFR) speaker for mono sound reproduction, two would allow for stereo use or louder sound. For that I use Yorkville PS12p and PS10p along with the sub (PS18s) and it is just an awesome setup. The PS12P is a really powerful and clean full range speaker suitable for small to medium venues and even works well outdoors with plenty of bass and headroom (1400W program power, for real).
So if I want to go streamlined and self-sufficient, I only have to carry my guitar, Helix, and one PS12P P/A speaker along with two cables (guitar>Helix and Helix>P/A), a pick, plus one cable for going XLR to FOH if desired. Easy load in/out and setup/teardown. The P/A speaker is the heaviest item, obviously but has awesome handles and is easy to carry - also if you are going direct to FOH, you wouldn't even need to bring the P/A speaker unless you want it as a stage monitor.
Hope this helps.
D