@mrvlhs I had to further troubleshoot this. Ultimately I isolated the issue to the advanced tab in the "digital audio interface properties" menu. With some amount of luck, I was able to solve this for good. Specifically the "default format" option seemed to be giving the UX2 issues with some programs. If you have already tried a full re-install, the only other thing I can guess is maybe changing the USB/Printer cable that connects the UX2 to the PC.