I had the same problem. It turned out it was caused by a need to update the Line 6 Monkey software. And I have NEVER in 4 years been able to update Line 6 Monkey without incident. You'll need to download it directly, instead of hoping that the ever-wonky Monkey software will be able to update itself. It'll probably throw out erroneous reasons why it can't do that, so here is the direct link.
Free Download