I am trying to emulate a lot of different band sounds. So sticking to the same signal chain is not a viable option.
It looks like looping or playing the same few notes open A, open G, muted E, muted B, bar chord, open chord etc. and using a meter in a DAW (monitor LUFS etc.) and then adjusting by ear for every preset is the way to get close. Then having a backup of 4db/eq option for the live gig is the way to go. Someone mentioned add a 0-4db gain control to the expression pedal of every preset.
If anyone has any other suggestions, I am all ears!