No regrets/remorse.
Here's why. I play rhythm guitar with our church worship team. We've moved away from amps - replacing them with Kemper heads going direct to FOH. Given advancements in modelers, this January I decided to try moving away from my rather large/heavy pedalboard for a number of reasons:
More control over my ecosystem. I'm not limited to the amps+cabs in the church Kempers. Have found some great clones from Signal Theory that work nicely with the guitars I play. The Helix also gives me greater flexibility in signal chain. I have a wide selection of solid drives and effects at the touch of the screen. The Helix allows me to put wet effects/modulation before OR after the amp+cab. I walk in, plug into the FOH, and play. Total set up time - 5 minutes.
Workflow. Preparation for a weekend set is streamlined with the Helix Stadium software compared with programming the RJM PBC/10 on my pedalboard. I can quickly achieve the tones in my head and focus on my parts in the song set. I've also reduced the number of devices requiring software updates.
Midi control. While I've been able to dial in my tones with the Helix effects and third party presents/clones, there are some pedals (like the Strymon TimeLine) that are hard to rival. I have a sidecar board (Pedaltrain Nano) with one or two pedals that sit in a stereo effects loop with preset selection and midi clock controlled by the Helix. Just finished setting that up today. I can place that loop anywhere in signal chain. Presets and tap tempo change automatically with the selection of song presets.
Sound. I'm getting tone out of the Helix that I've struggled to get from my pedalboard through both live amps and the Kemper. Plain and simple. For me, it's a better tool for artistic performance. That could be me or that could be the Helix, but it's what I'm experiencing. I'm also getting rave reviews from other members of the worship team, our sound enginerrs, and from the congregation.
I'm not getting any younger. Quite frankly, my old pedalboard and case (even with wheels and handle) were getting to be a pain to haul around. Heavy and cumbersome. The Helix sits on my desktop at home for practice and slides easily into a comfortable backpack for transport. The sidecar board and cables fit into an easy-to-carry soft case the size of shoebox. One trip from my vehicle to stage door (including my guitar).
Support. Given the Line 6 commitment to the Helix thus far, I feel that I can count on them strongly supporting this platform going forward. So far, so good. I also see third parties providing really solid amp clones and presets. There is a lot of choice out there.
That's all I got. I'm happy with my choice. It's confirmed every time I plug in.