Opened support ticket. Anyone having bug when you must press twice on patch to activate all blocks? . Not every time but it's very often. I'm on 2.60 version.
First response from Line 6 is that there is bug with HX Editor 2.60, but for me problem occurred even after FULL reset and after I made my new patches using HX FX hardware. I just used Hx Edit to export those patches. Maybe the bug from HX Edit "contaminated" my clean hardware again. Support ticket is open, so will post the updates.