Hi Bluesman27
I have a similar issue but the Guitar Input gate will get rid of the buzzing most of the time. Other things I've tried are a factory reset & reload the backup, worked briefly, reset the Global EQ, reducing EQ ouput gain and the amp channel output. The only time it doesn't buzz is when I connect to my computer with USB cable. It's really annoying as it never used to be a major problem until a few months ago. Different leads, guitars (even a brand new POD Go!), still buzzes. Pups are DiMarzio Air Norton, Tone Zone on Ibanez S770 & S771. Regards Ian C; Hope you find a cure.