Just got a new M1 Macbook, and am encountering the same issue. My HD500X shows up as a USB device but cannot be detected by HD500X Edit and is not visible as an audio device in my DAW. Half the reason I got this device was so I could connect via USB to my computer, very disappointing that we get nothing, not even a timeline, on when this support will happen.
Been using Line6 products since the original POD, very sad to see the lack of support here. Without workaround, I will have to consider other companies and products.