If it helps with your decision, I've been lucky enough to run GearBox (latest win64 install) on every windows version since XP and have never had an issue. Everything from a GuitarPort, TonePort/PodStudio, to XT Pro, X3 Live/Bean, etc... Just make sure you install all the applicable drivers for your hardware.
It's of course not a guarantee, but I love the UI of GearBox so much that I've never really let it go. Good luck!