Gentlemen,
I was getting distorted sound on my GX, UX2, and UX8 that so many others have described in this forum using Win 10 and a Cherry Trail tablet. It would seem to play at the wrong sample rate and sounded like some bad 8-bit Atari video game noise. This may apply to those with a Surface tablet too.
In my case the problem was with the Microsoft Driver for the "Intel(R) USB 3.0 eXtensible Host Controller".
Unfortunately Intel discontinued drivers and let Microsoft take over since Win 8.
I downloaded the Intel driver 5.0.4.43_v2 for Windows 7, disabled driver signing and edited the .inf to make it work with Win10.
After installing the old Intel drivers my Line 6 devices are working properly even through external USB hubs.