1. Input settings on User Bank 13 (A, B, C, D) are set incorrectly.
Tone 1 is set to GTR 1 + Variax and Tone 2 is set to Mic 1. Because the XLR and 1/4" inputs on the X3 Pro on the same channel cannot be used at the same time, this will not work.
The work around here is to re-save each patch in Bank 13 with the input setting on Tone 2 set to Mic 2.