My main advice is to make sure you enable the click track or add an in-time drum track before doing any tracking.  if you are recording real drums, record to a click-track.  It might even be helpful to program the drums, even if you are recording them acoustically, just to make sure everything is in time.  if you start trying to sync tracks to an out of time track, the whole project will be a mess.

Also, make sure you're recording in 96 kHZ, so long as your system can handle it.  You can set this by going Project > options.  or something like that.  dig around and you'll find it.

as far as how I like to arrange tracks, I like two distorted guitar tracks panned full left/right.  if they're in time, they should sound like one really thick track.  it's hard to get them that perfect, and they'll always sound a little weird until you add a drum track.  but if you already have a drum track, mute it when you play back your guitar tracks to make sure the drums weren't covering up any bad timing.

Some ppl like to quad track.  I've only done that once, and to do so I had two tracks panned full left and two full right.  I dropped the volume a bit on one left track and one right track.  So the quad part was just to add subtle reinforcement and thickness.

There's multiple theories on leads.  I like to do one track in the center.  Some people like to double it up.  Lots of ways to do that.  You can have both panned center and have one with less volume.  You could do equal volume, but then you're playing better be spot on, or it'll start to sound like a mess.  You'll get a slight de-tuned phaser/chorus sound as well.  Or you can pan them partial left/right - to give them a little space.

I try not to get too fancy with the recording stuff, but there's a whole world of possibilities.  Definitely experiment.