I have the 212 combo version of that head, its one of my favorite amps to use in this manner.

meambobo is right on about messing with the mentioned settings, but Ill tell you what I have found the be the best settings for me to get a good tight recto rhythm tone. Most of what I use is directly influenced by his High Gain tone guide, which I strongly reccomend. One thing I will say that I have directly observed with this amp - the power section and speakers are much more "full range" than those in the average guitar amp. Using Full models with this amp works VERY well. Since you are using the head, and I dont know what speaker(s), your milage may vary greatly. Anyway:

POD in Studio mode, using the Hiway 412 and 57 off axis

Treadplate - 61 - 24 - 39 - 69 - 37 power amp DEPs all 50%, ER = 12

FX1 - I go back and forth between putting an EQ after the cab to even out the high mids, or using a Screamer to tighten up the front end... both work for different situations.

EQ - Parametric, Low 64, High 55, Freq 47%, Q 50%, Gain 37%

Screamer - Bass 50%, Tone 52%, Treble 50%, Drive 0%, Output 67%

FX2 - Analog Chorus post-amp, with speed all the way down, depth at about 25%, mix no higher than 50%

FX3 - digital delay which I never use

Reverb - Hall, 12ms predelay, 20% decay, 50% Tone, 15% Mix

L/R 1/4" Outs in Line mode to the L/R "Slave In"s on the amp

You get no volume control on the amp this way, so you must set your overall master volume with the PODs little topside Master volume control.