Title says it.  Would be interested in hearing from any HD-series (HD500 in particular) POD owners using a QSC K-10 or 12 powered speaker for live performance.  I've been experimenting with one and find there are a lot of odd-sounding high harmonics when using overdriven amp sounds.  At this point I'm not sure if this going to be a problem or not when playing with others.

I did quickly discover that all amplifier cabinet emulations require bass rolloff betow 200Hz. to avoid "woofy" tones on the lower strings. 

FWIW, I'm playing a Variax JTV-69k through this setup.