Hello,

I have a Spider2 and 4x12 cabinet, and once I got through with looking at others serttings, and threw out what I used on other amps, I think I found my idea of the famous sound (with good humbucker):

Amp Model:

Green Insane

Drive:

3 o'clock

Bass:

2 o'clock

Mid:

4 o'clock

Treble:

1 o'clock

Channel Volume:

MAX, 5 o'clock

Effects:

None

Delay:

8:30 o'clock

Reverb:

10 o'clock

I have the STOMP/PRE-AMP turned on as well as the NOISEGATE.

For a single coil guitar, I would increase the drive, turn bass up to 3 o'clock, maybe 4 depending on your pickup.  IF it is a little too strong for you, back down the Channel Volume a click or 2.

Good luck with those, I didn't like the CRUNCH model, either red or green, never got it to feel right for the EVH sound.

My biggest issues was I first tried to use settings that worked on other amps.  Once I got fed up with the settings not sounding like they did before, I  started from scratch and found what I wanted.  I have learned that for Line 6, don't apply what might be the right settings on other amps, play with the settings from scratch until you find the sound you want.

David