I have been using my HD500 thru a Crown XLS1000 into a custom 2x12 for 2 years now, I love it. Any tone- any time. The 2x12 has a Mesa black shadow and Celestion Lead 80 and it's decent sounding imo, used to run a Mesa Mark IV and 5150II head thru same cab and created tones similar enough that I don't have to lug around the expensive heads and get close enough tones for live/ road use. BUT I'm very much on the verge of going w a FRFR monitor instead , the sound is just cleaner and I think it's more efficient and effective than trying to compensate for or even color the existing tone(using a 2x12) - just some advice. I have done the 4x12 thing, the 2x12 thing, the Direct thing, and the cable method of my HD500 adding fx AND switching the channels on my 2 amp heads simultaneously. While that was my favorite sound, no doubt, lugging around that valuable and financially unreplacable equipment was just getting tiresome. I am very pleased w the direct / FOH sound actually, its dialed in great. But anyway, I recommend considering ditching the cab/power amp route w these units and just go direct to FOH w a FRFR on stage as a monitor.