Similar issues here. I've been using L6 gear for over 12 years. POD XTLive, Variax 500, GX, DT50 212 Amp, HD500, JTV59.
Monkey & Licence Manager doesn't work on my iMac running High Sierra 10.13.
L6 Updater only shows a blank, black screen asking for which device to update, but none are shown. Cannot find a solution via the User Fora, nor does theL6 'knowledge base' help. Every piece of L6 software I start, besides Updater, "This app is not optimised for your Mac. It needs to be improved by its developer..." etc. Several apps (Monkey & Licence Manager) won't run at all.
When the L6 stuff dies from here on I will never replace it with L6 gear again.