eypee

I'm hearing static through my headphones in phones out and through my speakers when i go analog out. I hear static when listening to spotify, editing on premiere and so on. When i disconnect my line 6 studio ux2 and listen through the inbuilt sound on my mac, there is no more static. I have the newest drivers and use a 5k 4GHz Intel Core i7 imac on macOS Sierra. is there a solution for this one yet? maybe adjust latency settings?? i did that once but i forgot where. Please help! Eypee