I second the cable reference from voxman55. Big difference using balance cables out from the PodGo to the Headrush and the contour set to flat on both vs. instrument cables. I have two I run in stereo using balanced cables and it sounds great! Just for reference, I have a Line 6 Spider IV HD 150 head and 4x12 cab, an EVH Stealth LBX and 1x12 cab as well and I think the Headrush and PodGo combo have a great sound. Not running any particular high end guitars either - stock EVH striped series, Jackson Soloist (1991) with Dimebag Duncan at the bridge, ESP LTD GL Kami4 (stock), ESP LTD KH-602 (stock), a Mexican Fender STD Strat S/S/HB (stock), 77 Fender Tele (stock), an ovation elec/acoustic and a new Kramer 84 (stock for now) - nothing special there and it all sounds great through the Pod and HR rig...