Thanks for the quick reply. For now I'm going with the two XLR. This is pretty much an at-home setup, at least for now. So far I've only tested with MP3 output, first from laptop and then through HD500. Both sounded very good for single speaker. That also helped me go through the speaker DSP menus and settings. Once I get everything setup in the room I'll plug the guitar in and start figuring out those settings.
In the past I've used regular amps and have never really been satisfied, whether going through front, FX return, even 4CM (way too many variables with that one). Since this is primarily a hobby I finally settled on using the most straight-forward method I could find. After a lot of reading on a lot of boards that seemed to be using a FRFR solution with studio/direct setting on HD500. One speaker seems like enough for now to setup some simple patches and concentrate on getting familiar with the amps and DEP. Figure on starting there and working my way into the effects. Should be a lot of fun!