Sorry about that, I'm running Windows 7 and using REAPER as my DAW. Although I'm not sure it should mater about which DAW I'm using as I am also experiencing the skipping/crackling sort of sound with other applications as well as online (Media Player, iTunes, Youtube, Soundcloud, ect.) And as I mentioned there seems to be no problem with the cables because they work fine with my M-Audio.
My only thoughts are that I overlooked some small detail somewhere, I could try the balanced outputs, or (God forbid) there's something faulty with the hadware? Any other ideas?