I answer myself to myself.
When I use Helix as an audio interface in a Live 9 project, the Helix generates lots of clicks and artifacts.
To correct this huge problem, I have to adjust the buffer Live 9 on 2048 samples.
Also, in Live 9 and on my Mac, impossible change the sample rate, it remains blocked on 48000.
I redid the test with my RME BabyfacePro audio interface (with the same Live 9 Project ), I have no problem, no clicks, reading and recording are perfect. The buffer set to 128 samples.
I still say that the helix a big trouble on this specific issue and is unusable as an audio interface.
I am disappointed that Line 6 does not communicate on this important issue, or postponing the problem on the Mac system 10.11
It is abnormal to have a unit cost that price and not have satisfaction.
Mac Os 10.11.2
Helix firmware 1.04.2