I uninstalled the drivers AND disabled the only other audio interface (onboard) in device manager!
I have the same issue on two different Win10 computers, I have analyzed the crash dumps, and trust me, as an IT Director by trade, I have troubleshot this and isolated it to the L6PODHDPROSE64.sys driver. I've had this issue for a few years now. I'm also not the only one at whit's end after extensive troubleshooting (see other threads).
I don't want to but I read one other person ended up buying an interface to connect the Line 6 instead. Someone else also using something else as the primary sound interface and using the Line 6 for inputs only. Problem went away in both cases. I wish Line 6 would just release a proper new driver or otherwise acknowledge the issue.