I'm a little confused about some of the phrasing in your post, but here are some things to check: Is Windows 10 recognizing the UX1 as an audio device? Is Reaper audio device settings configured to use the UX1? If it's still not working, will Reaper work with selecting the default Windows sound device as the audio device? The UX1 should have POD Farm that came with it. When you run POD Farm as a standalone application and play guitar through a patch, does it generate sound? Do you have headphones or speakers plugged into the UX1 (as opposed to your normal computer audio jack)? If none of this works, it'll take some deeper troubleshooting. I use Reaper on Windows 7 with a UX2, and could put a bit of time into a Skype screenshare later on today if that would help. Clean Master Facebook Lite Mathway