For better results in terms of sound quality and latency, it is recommended to use an audio device (Scarlet Focusrite, Presonus, ecc.). The audio device is connected to the PC and you can connect your guitar directly to the audio device and processing the sound with cubase using some plug-in. Or you can connect the digital outs of your Spider (but I don't known if there are digital outs in the spider v 60) to the balanced xlr input of the audio device and record the guitar processed by the Spider in cubase.