I've been using the POD GO for about 3 weeks now exactly as you describe.
One thing I have found however is that certain setup chains, particularly with a lot of distortion/gain get lost in the mix and lack any power to cut through.
I base everything on a 'very clean base' setup and usually add the Minotaur and change the FX Loop to a parameter change for channel volume or the amp block or drive on the kinky boost to increase the signal.
As for monitoring, I just send the AUX from the PA back to a wedge monitor or in-ears, depending on the venue.
