I realize this is an old thread, but the problem still exists. I've seen arguments to blame the OS instead of Line 6. I don't see anybody to blame. I'm on the fence about it. "It's simply outdated hardware," but is it really? The hardware is still perfectly functional, these aren't iPhones, we don't need faster processors, or more features. We just need compatibility to keep what I consider my awesome purchase from an awesome company up and running. Focusrite is on Gen 3 of the Scarlett series, but I bet the Gen 1's are still up and running, because the company pressed forward with the series, they didn't abandon it... but for how long?
With Nvidia however, the latest drivers will work on your brand new 4090 series card, or your GTX780 from 2013. This is the right way to do it. I'm using a Toneport UX8, and disabled memory isolation to keep it going. I'm impressed that drivers even work in Windows 11 but they do. They just need to fix the memory isolation compatibility issue, but otherwise it works, so I do have to give credit where it is due, they just need a little extra push in the right direction.
With that being said, I recently bought a POD Pro, knowing full well that support was over. I bought it for nostalgic purposes only, but I do run Windows XP in a VM on my machine, and pass through a USB-Midi adapter to the VM and run the Line 6 Pod Pro Edit program so that I can still access hidden features like noise gate threshold and such. It's actually better than running it natively, because I don't have outdated Java 1.6 running on my Windows 11 machine, and I can scale the VM window to make the Line 6 Edit interface nice and big. Also the audio processing is done in the Pod, not in the software, so no audio driver clicks or pops or anything else, it works perfectly.
Going in blind on a new product though, and not knowing when the perfectly capable hardware will loose support isn't a good feeling. You can't even accuse L6 of purposeful obsolescence, because they never released a comparable updated device to the UX8 for people to purchase. I love L6, but wouldn't buy anything from companies that don't follow the Nvidia product support lifecycle, and unfortunately, few do. I get it, hardware ages, support must end, but compatibility updates do not have to end. Build brand loyalty, don't degrade it. Nvidia has a loyal diehard fan base, and I'm sure device compatibility has something to do with it, because even those GTX780 guys are still in the game.