I don’t know if anyone else has mentioned this, but I run my guitar into a external wah then into the helix and one of the analog outs goes into a fender twin reverb reissue, everyone knows this is a loud amp but with the helix in front I can run it a bit hotter and use the volume on helix to tame it to bedroom levels! I know better not to use cab sims with a real amp but with how clean the twin is, I find I get great representations of various amps using the pre blocks as a gain stage pedal. I know this is all obvious, but it’s like finding the toothpick in your Swiss Army knife.