Thank you guys, for your support!
Today I took a few hours to copy and started rework my patches to full amp models. It's quite a big difference..
I'd only tried them in my home studio, so I think I must tweak and fine tune them in a real PA?
But I'm still confused about my DT50, Why did it happend and can it happend again? I tried it with my pod today and it's working.
I have two new live gig next week, on Friday and Saturday, and it must working. I shall contact my reseller of my rig after the weekend.
I haven't so much time to tweak new patches, and I must do every patch three times because I have three quite different guitars, Les Paul, Stratocaster, Telecaster (I even use them for backup if I have stringbreak.