Hi TBoneous,
yes, in my case this is the 'ticket' for electric and acoustic guitars ... not because of the different pickup-systems (electric vs. acoustic guitars), but because of the HD500(X) in the signal-chain ...
I use the HD500X as (full) modelling-unit:
in case of an electric guitar a patch with a matching amp (Fender , Marshall , VOX ..)
in case of an acoustic guitar a patch with (for example) a Tube Compressor and an EQ
My goal is: the output-signal from the HD500X (L6 Link / XLR) is 'ready' for amplification without further toneshaping.
In other words: The 'only' purpose of the L2T - in my case - is the (FullRangeFlatResponse-)amplification of HD500X-Output
... others may have different experiences ...