Nothing Worked, reinstalled Windows with new HD, tried all USB (including a powered hub as per the guide). Tested on 3 systems with 3 different windows versions (7, 8 and 10), all driver combinations, 5 different high quality USB and mono cables (That work well with my other equipment). Line 6 monkey says drivers and USB firmware are all OK. no errors in device managers, no power issues on my USB ports. I am going mad trying to figure this out. All ASIO4all settings combinations. 3 different DAWs.
I sunk a lot of money in peripherals just to use my card again. I really loved the Toneport UX2 and would not want to part ways with it.