This a security issue in Os High Sierra, I first found the issue not from installing line 6 drivers, but making changes on my SSD even as administrator I was set to read only. . I had to disable the new security,restart, then switch permissions me to read/write, restart, enable security (it's actual default is for the roots level) then restart and it was her old start.
With the line 6 drivers if you don't see a notification then you have to accept the driver in settings/security