I thought I'd share my experience. Just received the LT today. Updating the firmware to 2.30 and installing the driver & HX Editor was piece of cake. Then after playing with it for an hour it just showed the No Device Connected red sign. I tried everything from rebooting the LT, to rebooting my PC, changing the USB cable, plugging it to all combinations of HUB/USB2/3/etc, uninstalling and reinstalling the driver, hard reseting the LT. Finally I thought how about the usual Windows 10 trick: Run as Administrator - and voila, it worked. So look for the %PROGRAMDATA%\Microsoft\Windows\Start Menu\Programs\Line6\HX Edit\HX Edit.lnk link, right click on it, choose Properties, and on the Compatibility tab, check the last check box 'Run as Administrator'. Worked for me.
