Yes, the focusrite is the hub of my sound system/DAW. It remains powered on 100% of the time while I'm working, however, the helix rack only comes on when I'm tracking guitars. The focusrite will work just fine clocking off the helix using S/PDIF but the focusrite won't fall back to its own internal clock when the helix shuts off. So if I shut the helix down, the sound going through the focusrite will cut out entirely. I don't want to keep my helix on 100% for the clock nor do I want to change the clock source on the focusrite every time I want to track guitars.