@theElevators - Yeah, the clicking and popping 5mafr5br reports in his post does sound like a cable issue, potentially.
For me, this is not acting at all like a cable issue. This output cable (and the guitar cable) is a relatively new cable that I keep as a backup, just a few years old, good quality, and lightly used a few times, always carefully "union wrapped" (over/under), and not stepped on much - mostly routed out away from where we stand. The connections and plugs are in great shape. There's heat shrink around the solder joints so I can't see the connections, but it's all clean, no damage to the heat shrink, strain reliefs and jacket or plugs.
The sound just cut out all at once, no hint of an issue, no crackles, etc. ever before that. The input and output blocks were responding to the guitar, so with the power still on we swapped in a different output cable to the PA with no improvement, still dead. After power cycling both the swapped and original cable worked fine.
This is acting most like an output protection circuit tripped, perhaps a thermal shut off tripped, though I run at half volume for the line out (so most of heat is probably in the processor(s)), or possibly power-on-reset tripped and reset a processor or a serially programmed device like an active resistor type of component in the output chain. I'm not familiar with the architecture enough to say more specifically what it could be, but it's that kind of an immediate reset or "shut off" behavior. A mains surge, high noise or droop might cause this type of thing if the internal DC power supply is not well filtered and bypassed, for example. Switching presets, which I imagine should reprogram every stage, did not bring the output back, only a full power cycle.
If there is some sort of event log to check later that would be really helpful for debugging. Not sure if the Helix LT provides any? Cheers