I am resetting the defaults on the Amplifi, and found JC120 for my clean tone. It really sounds great with my Sheraton. I have SD Jazz in the neck ans Seth Lover in the bridge, and the thing just chimes, in a smooth mellow sort of way, but the shimmer is def there.
So, what I have decided to do for the 4 presets is to start basic. Clean, crunch(for rhythm and low end riffs), lead, and I haven't decided on the 4th yet(probably some dirty blues tone). If I keep the defaults just to basic amp/cab. then I can add whatever effects to whatever it is I happen to be doing.
I figure I gotta just try different things/ways of using the tech out, and see what works for me, cuz I think I have landed on the gear that I like, for the long term.