I see you are having trouble with harshness and your highs... What I recommend is to adjust the sag, Bias, and Bias excursion. The Bias and Bias excursion will help you hear the higher notes more or less depending on what you want and the sag will give it a more low end, crunchy sound to it. I use the HD500x live through a PA system and once I got my patches sounding good it all worked out fine. Also try adjusting the EQ on the PA system I like to just turn that off and just use my HD500x's EQ. And turn down the gain on the PA system and if it has it add a noise gate effect to your channel. ALSO if you want more punch and stuff to act more like a Cab then adjust the cab settings/mic setting and it will make a HUGE difference. :)