No offense taken.
I was merely trying to understand your question.
Myself, I'm a touring guitar player with approx. 100 gigs per year, and have been for the last 15 years.
I've using the relay with Pods, Marshalls, Axe-Fx, random amps provided by the venues, and I've never experienced any difference. Same goes for my bass player and 2nd guitar player.
Cables? yes.
I have however experienced wifi lollipop...but that's understandable to me, cause the relays works in the wifi space :-) So in all simplicity, I'm using the Helix on a gig tonight, enter stage in 1 hour, and it worked fine on soundcheck...also today. hehe