I think the biggest difference between the Fractal and the Helix is the on board cabs. Some like the stock Helix cabs, I think they are OK but when I load my favorite IR's, it's night and day. Keep in mind, the Axe cabs are all third party IR's, so if you prefer IR's to the Helix cabs, you're starting behind the 8 ball right off the bat.
I load the BE into the Helix with an OH Marshall Basketweave G12M20 speaker, gain = 7.5, bass = 8.5, mid = 6, treble = 5.5, presence = 4.5, master = 3, and I'm done. It is virtually indistinguishable from a real mic'd BE. Can't get any easier than that.