Thanks all. Fantastic and very helpful responses. As a first impression, you all seem to make up a very helpful community here.
While I don't have much experience with it, I have been using Guitar Rig 5 more and more, with my Presonus Eris E5 monitors. I imagine that they would work great for the HD500x, but if I am going in, maybe I'll grab the L2T/L2M. I love the idea of stereo.
Hopefully Line6 puts some better OEM samples on the unit. If I test a combo modeling amp in a store, I expect the preset dial to have some typical basic samples that will give me clean, classic, metal, etc to quickly sample some capability. I just thought the first 10 banks would have been something like that. Had that been the case, I may have walked out with one, but as some of you have said, I too have been listening to video after video trying to discern what is room acoustics, etc.
Thank you again for all the helpful replies. I did come across the Axe-FX II, but that is a different world altogether. Granted, it goes for the "feel" (blooming delay maybe) of tube, but at that price, I think I'll leave it to the pros.