I would just say that "less is more" when it comes to gain.
On its own, I sometimes think that I don't have enough gain in my guitar tone using the Uberschaal model, but when I record & hear it back, it's plenty fine, and dynamic.
My recordings are in the 2 guitarist perspective, ala Judas Priest, Iron Maiden, etc... and my recordings always remind me that I am serving the recording best with the sweet spot of gain.
Yesterday, I was playing on my church worship team, and I ran across the same scenario playing along side an acoustic, J-Bass, Keys, and a drummer with 3 vocalists. During sound check, again, I'm thinking, "do I have enough gain?", but then when the rest of the band fired up, I quickly put those concerns to rest as my tone fit the entire band mix appropriately.
Because I spend a great deal of time creating my presets in a recording environment in a band mix context, FOH barely does anything to my signal other than a slight rolloff of some low end, according to their room, and a unity gain signal. That's it, no gate, no comp, just good gain staging with minimal subtractive eq.